Oral Medication: Viagra, Levitra or Cialis?

Oral Medications


Now days there are three oral drug medications that has been approved for the treatment of erectile dysfunction:


1. Sildenafil citrate
Well known as Viagra, available on 1998, become as first and prime treatment to impotence. Developed and being marketed by Pfizer. Other trade name is Revatio.

2. Vardenafil
Treatment for impotence that is available by 2003 and it’s famous under trade name Levitra world-wide and Vivanza in Italy. The pill was developped and marketed by Bayer, GSK and SP.

Levitra

3. Tadalafil
Third drug that has been used for treating erectile problem by the end of 2003. World-wide known as Cialis and Tadacip in India. It has been developed and marketed by JV Lilly ICOS, LLC.

All three belong to a class of drugs called selective enzyme inhibitors. Sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) block the enzyme phosphodiesterase type 5 (PDE5), so called PDE5 inhibitor. Blocking this enzyme helps maintain levels of cyclic Guanosine MonoPhosphate (cGMP), a chemical produced in the penis during sexual arousal. Balanced levels of cGMP causes the smooth muscles tissues of the penis to relax and increases blood flow.


PDE5 inhibitors (Viagra, Cialis and Levitra) are a good choice for men at any age and in any ethnic group who are in good health and who do not have conditions that preclude taking them.


Effectiveness of PDE5 Inhibitors.
• Tadalafil (Cialis). It appears to take effect in 15 to 30 minutes after consumption. It is the only oral ED treatment shown to improve erectile dysfunction for up to 36 hours in most men. A randomized study of 2,102 men in the British Journal of Urology found that nearly two-thirds of men reported successful intercourse attempts 24 to 36 hours after taking the drug.


• Sildenafil (Viagra). Studies indicate that overall, sildenafil may help more than 70% of patients achieve sexual function, with results depending on indication conditions.


• Vardenafil (Levitra). Extensive clinical studies have shown that vardenafil improves erectile dysfunction in up to 85% of men with the condition. It also has shown to be work well in patients with diabetes and in those who have had a radical prostatectomy.


Studies indicate that PDE5 inhibitors are safe and effective for many men whose erectile dysfunction is related to the following conditions:
      • Hormonal problems or psychologically induced impotence. These men achieve the highest     success rates (80 - 100%).
      • Stable heart disease. However, PDE5 inhibitors should not be used by men who take nitrate drugs for chest pain or heart problems.
      • Mild to moderate congestive heart failure. (A randomized study in the Archives of Internal Medicine found that men with moderate congestive heart failure and ED can safely use sildenafil to improve their sexual function and overall quality of life, provided the men are not taking nitrates for their heart condition. In addition to exhibiting improvements in ED, the study participants taking Viagra also showed higher scores on depression screening exams. Other research has also suggested that Viagra is safe for this group of men and may even improve exercise capability.

Controlled hypertension
• Controlled diabetes (type 1 or 2). Diabetes has been associated with a lower than average response to Viagra. Still, in a 2002 study over half of patients with type 2 diabetes achieved at least one successful sexual event.

• Kidney conditions, including those that require chronic dialysis and kidney transplantation.
• Parkinson's disease. There is even some evidence that sildenafil may even have properties that improve depression and help brain functions (attention, memory).
• Depression. PDE5 inhibitors may help men who take antidepressant drugs that cause sexual dysfunction, notably the popular serotonin reuptake inhibitors, such as Prozac.
review from healthcentral.com


Youtube on PDE5 Inhibitor

Natural Remedies For Erectile Problem

If you feel that NPT just work fine with you then you do not have physical problem with your penis erection. Your erection just fine but you need psychological treatment to get sustainable erection (long hard erection) so that your sexual intercourse can be as long as you and your partner wish.

Most of the cases can be treated by natural herbs and natural remedies that are safer than using chemical based products such as Via gra, Cialis or Levitra.

Please read

some review from healthcentral.com about natural remedies;

Herbs and Supplements

Generally, manufacturers of herbal remedies and dietary supplements do not need FDA approval to sell their products. Just like a drug, herbs and supplements can affect the body's chemistry, and therefore have the potential to produce side effects that may be harmful. There have been a number of reported cases of serious and even lethal side effects from herbal products. Patients should always check with their doctors before using any herbal remedies or dietary supplements.

The following are special concerns for people taking alternative remedies for erectile dysfunction:

Yohimbe. Yohimbe, which is similar to yohimbine, is derived from the bark of a West African tree. Side effects include nausea, insomnia, nervousness, and dizziness. Large doses of yohimbe can increase blood pressure and heart rate and may cause kidney failure.

Gamma-Butyrolactone (GBL). GBL is found in products marketed for improving sexual function (Verve, Jolt). This substance can convert to a chemical that can cause toxic and life-threatening effects, including seizures and even coma.

Gingko.

Although the risks for gingko appear to be low, there is an increased risk for bleeding at high doses and interaction with vitamin E, anti-clotting medications, aspirin, or other NSAIDs. Large doses have also been known to cause convulsion. Commercial gingko preparations have also been reported to contain colchicine, a substance that can be harmful in people with kidney or liver problems.

L- arginine (also called arginine). Arginine may cause gastrointestinal problems. It can also lower blood pressure and change levels of certain chemicals and electrolytes in the body. It may increase the risk for bleeding. Some people have an allergic reaction to it, which in same cases may be severe. It may worsen asthma.

DHEA. DHEA is a supplement related to certain male and female hormones. Studies show inconclusive results in its treatment for erectile dysfunction. DHEA may interact dangerously with other medications.

Aphrodisiacs. Aphrodisiacs are substances that are supposed to increase sexual drive, performance, or desire. Some examples include the following:

• Viramax is a well-marketed product that contains yohimbine and three herbal aphrodisiacs: catuaba, muira puama, and maca. It has not been proven to be either effective or safe, and interactions with medications are unknown.
• Spanish fly, or cantharides, which is made from dried beetles, is the most widely-touted aphrodisiac but can be particularly harmful. It irritates the urinary and genital tract and can cause infection, scarring, and burning of the mouth and throat. In some cases, it can be life threatening. No one should try any aphrodisiac without consulting a doctor.

Other Alternative Products Marketed for Erectile Dysfunction.

Vinarol is an over-the-counter supplement that was recalled after reports surfaced that it contained the same ingredients found in Viagra. Herbal supplements sold as Viagro and Vaegra have no association with Viagra.

review by www.healthcentral.com

Let's watch video about ED.

Self-test Your Erection; Psycho or Physical?

Erection self-test

Definition

An erection self-test is a method to determines a man's ability or inability to achieve an erection during sleep.

Alternative Names

Nocturnal penile tumescence (NPT) stamp test; Nighttime penile tape test

How the test is performed

A strip of four to six postage stamps (any kind) is used for each test. The test needs to be done for 3 nights. The man needs to wear brief-type undershorts that have a fly. Place the penis through the fly, leaving most of the pubic hair against the body.

Wrap the strip of stamps snugly around the shaft of the penis. The stamps need to overlap so the overlapped stamp can be moistened to seal the ring. When the stamp has dried, carefully place the penis back inside the shorts and wear them while sleeping. (They help protect the stamps from falling off).

In the morning, check to see if the stamp ring has been broken along the perforations. If the tearing of the stamps awakens the man during the night, check for an erection and how rigid the erection is.

How to prepare for the test

You will need to buy some stamps. Do not drink alcohol or take a sleep-inducing or sedative medication for at least 2 days before the test.

How the test will feel

The stamps may feel unusual. The test should be done until 3 nights of comfortable, uninterrupted sleep is achieved.

Why the test is performed

The test is done to confirm if a man can have an erection at night. All men with normal physiological erectile function will have an erection during normal sleep. The test may help determine if the cause of erectile dysfunction is psychological or physical.

(As per www.healthcentral.com review)

So what do you think, go nearby pharmacy ask for NPT and try for yourself. Good luck.

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